北朝年间,各方势力割据,江湖动乱不安。“南刀”李徵(胡兵 饰)在湖湘地界建立门派四十八寨,收留落魄的武林人士,并从此避世而居。但随着李徵逝世,江湖名门也相继败落。 多年后,李徵的外孙女周翡(赵丽颖 饰)在洗墨江被一位自称谢允(王一博 饰)的青年男子意外救下,两人从此结下不解之缘。 半年后,周翡和谢允再次在霍家堡黑牢相遇,却同时遭到江湖黑暗势力“地煞山庄”几大高手的追杀,两人因此卷入一场江湖的阴谋浩劫中。 周翡受江湖前辈指点,始终磨砺自己的刀法、并凭着一股“狭路相逢勇者胜”的勇敢杀地煞、平叛乱、擒敌王、救流民;而谢允自始至终陪伴在周翡身边,为她指点进退,二人携手共进,生死不弃,一起平息了一场场江湖动乱。以周翡、谢允为代表的一辈江湖新秀们从此成长为真正的“有匪君子”,周翡也终成一代“南刀”少女宗师。Several years ago, the emperor secretly ordered the hero Li Hui to form a mountain stronghold consisting of bandits in order to keep the pugilist world under control. His daughter, Li Jin Rong, leads the stronghold after Li Hui's death and gives birth to Zhou Fei after marrying scholar Zhou Yi Tang. Zhou Fei's attempts at escaping have always ended in failure, though Li Jin Rong allows her daughter to go and experience the world outside after her 16th birthday. She meets Xie Yun again after he saves her from drowning during her first escape attempt, and they embark on an adventurous journey through wulin together.