Luke(杰克·约翰逊 Jake M. Johnson 饰)和Kate(奥利维亚·王尔德 Olivia Wilde 饰)是一对好朋友,两人在同一个酿酒厂工作,亲密无间,堪称知己。同时Luke有一个相恋多年谈婚论嫁的女友Jill(安娜·肯德里克 Anna Kendrick 饰),而Kate也有一个男友Chris(朗·里维斯顿 Ron Livingston 饰)。四人相识之后便经常进行四人约会。不久,Chris提出了分手,Kate开始了放荡的生活,Luke不忍看Kate日渐消沉,然而只是朋友的他又能做些什么呢?Luke and Kate are co-workers at a Chicago brewery, where they spend their days drinking and flirting. They're perfect for each other, except that they're both in relationships. Luke is in the midst of marriage talks with his girlfriend of six years, Kate is playing it cool with her music producer boyfriend Chris. But you know what makes the line between "friends" and "more than friends" really blurry? Beer.