杰克(Jesse Metcalfe 杰西•麦特卡尔菲 饰)的姐姐莉莉(Kiele Sanchez 基拉•桑切斯 饰)沉湎于死亡漩涡,多次自杀未遂,最终被送往精神病院强制治疗。为了解救失去自由的姐姐,杰克假装成精神病人混进门禁森严的精神病院。偶然间,他发现医院内的吉尔尼迪大夫竟然用病人做试验。他强迫并人们服用一种药物,并将他们变成嗜血狂魔。 得知真相的杰克策划逃跑,他们触动了医院内的电子保全系统,精神病人全部跑了出来。当然,也包括穷凶恶极的吉尔尼迪医生和他冷酷无情的吸血军团……Metcalfe will play a man who pretends to be crazy in order to save his sister (Sanchez) from being involuntarily hospitalized. Once inside the institute, the siblings discover that a doctor (Stormare) is using his patients like lab rats, forcing them to take a drug that turns them into flesh-eating psychopaths.