伊丽莎白(诺拉•琼斯饰)被男友抛弃,伤心又苦恼的她把钥匙扔在咖啡店里。咖啡店的老板杰瑞米(裘德•洛饰)保存了很多钥匙,每把钥匙都埋藏了一个伤心的故事。伊丽莎白爱吃店里没人点的蓝莓蛋糕,在某一晚决定离开纽约,穿越美国到处看看。在旅途上认识了明明深爱却困囿彼此的分居夫妇,还有豪爽爱赌却鲜回家看望父亲的少女(娜塔莉•波曼饰),每到一个地方她就给杰瑞米写一张明信片。以他人为镜,伊丽莎白找到了爱的真谛,回到纽约,看见等待自己的杰瑞米,可以幸福地,再吃一客蓝莓蛋糕,放心享受爱的欢愉。Elizabeth's heart is broken. For solace, she drops in late at night a few times at Jeremy's diner for blueberry pie a la mode; they talk. Once, he watchers her sleep, her head on the counter. Abruptly, she leaves New York City to get away from her pain. She works a couple of jobs in Memphis. There, a heart-broken cop is drinking himself into oblivion, his ex occasionally showing up where he drinks and Lizzy works. Then, she's in Nevada, working at a casino where she uses her savings (she wants a car) to stake Leslie, a busted gambler, in a high rollers' game. After, Beth drives Leslie to Vegas where Leslie's estranged father lives. Broken relationships. What about Jeremy?