凯(约翰·卡萨维兹 John Cassavetes 饰)有着一个外表单薄脆弱的妻子罗斯玛丽(米亚·法罗 Mia Farrow 饰),自从他们搬到新公寓后,凯就和邻居一对老夫妇相谈甚欢。而罗斯玛丽却并不特别喜欢这对邻居,令她感到不适的,还有接下来的一连串怪事。 罗斯玛丽看 到了自杀的女人,在日渐诡异的生活气氛下,她还做着毛骨悚然的梦。梦中,有一个长毛怪物侵犯自己,罗斯玛丽从噩梦中醒来不久,竟得知自己已有身孕的消息。邻居老太前来照顾罗斯玛丽和腹中婴儿,然而,罗斯玛丽却渐渐怀疑,一切的古怪事情,都来自于这个表面和善慈祥的邻居,甚至还有自己的丈夫!他们正在合谋计算罗斯玛丽的婴孩。到底是罗斯玛丽的幻觉还是确有其事?当她看到出生的婴儿眼中竟无瞳孔时,罗斯玛丽知道,魔鬼的气息近在眼前。Rosemary and Guy Woodhouse move into an apartment in an opulent but gothic building in Manhattan. Their landlord Edward "Hutch" Hutchins attempts to dissuade them from doing so: the building has an unsavory history. They discover that their neighbors are a very friendly elderly couple named Roman and Minnie Castevet, and Guy begins to spend a great deal of time with them. Strange things begin to happen: a young woman Rosemary meets in the laundry commits suicide, Rosemary has strange dreams and hears strange noises and Guy becomes remote and distant. Then Rosemary falls pregnant and begins to suspect that her neighbors have special plans for her child.