在人间之外的天堂与地狱之战绵延不绝,双方都在为自己争取强力的战士。中情局特工西蒙斯(迈克尔·加·怀特 Michael Jai White 饰)厌倦了杀戮的任务,向上司威恩(马丁·辛 Martin Sheen 饰)提出退出,岂料却在朝鲜执行任务时被威恩害死。坠入地狱的西蒙斯与恶魔马里波吉亚达成协议,同意为它统率地狱军队来换得再生报仇的机会。被恶魔雪藏五年的西蒙斯再生回到人间,以再生侠之名示人,并在恶魔走狗——小丑的引领下向威恩复仇。此时研究生化武器着魔的威恩试图统治世界,而他的死亡会引发全球陷入生化灾难。为了复仇的西蒙斯能置全人类的安危于不顾么?An assassin named Al Simmons is double-crossed and murdered by his evil boss Jason Wynn. Al makes a deal with the devil and returns to earth as Spawn to see his wife. He is ordered by the devil's minion, The Clown, to kill Wynn. Wynn has made a deal with the clown too and is suppose to destroy the world with a deadly virus that will help start Armageddon and allow Hell to attack Heaven. Spawn must choose between Good & Evil.