从婴儿时被母亲并排的放在便利店门口起,杰(杰森•缪斯 Jason Mewes 饰)与鲍伯(凯文•史密斯 Kevin Smith 饰)这对贱友与便利店的缘分便开始绵延,然而店主不堪忍受两人整日在门外闲晃,报警将他们驱逐。杰与鲍伯坏运气还没完,一部以他们为主人公的漫画改编电影即将开拍,除了片方一分钱也没给他们,网上还充满了对他俩的谩骂与嘲讽,愤怒的二人组决定从新泽西赶赴好莱坞,阻止电影的拍摄。两人于路搭上了动物保护主义者杰斯特等四名美女的顺风车,杰迷恋杰斯特,答应帮助偷窃被用于实验的猩猩,谁知这四名女子实际是珠宝大盗,杰与鲍伯带出猩猩后被警方认定为恐怖主义者。两个人和一只红毛猩猩,在警方围堵中继续向好莱坞前进……Jay and Silent Bob Strike Back is a tale of adventure on the open road. When Dante and Randal (of Clerks fame) get a restraining order to keep the punchy Jay and his hetero life-mate, Silent Bob, from selling drugs in front of the Quick Stop convenience store, their lives are suddenly empty. They find new purpose when their friend, Brodie, informs them a movie is being made featuring two infamous characters based on their likenesses. After visiting one of the creators of the Bluntman and Chronic, Holden McNeil, they set out to get what fat movie cash they deserve and hopefully put an end to people slandering them on the Internet. Along the way, they learn the rules of the road from a hitchhiking George Carlin, ride with a group of gorgeous jewel thieves, and incur the wrath of a hapless wildlife marshal for liberating an orangutan named Suzanne. The quest takes them from New Jersey to Hollywood where a showdown involving the police, the jewel thieves, and the Bluntman and Chronic filmmakers will decide the fate of Suzanne, Jay, Silent Bob, and their good names.