魔鬼卡车有巨大的车轮、钢铁车厢和超强功率,可以碾碎任何挡在它前进路上的东西!在荒无人烟的1-55地区,有一辆魔鬼卡车赋予这个名字新的意思,不只卡车是恐怖的,还有它的司机。两名大学生开车误入魔鬼卡车的通道上,他们要担心的不只是充满了被截肢的乡巴佬的酒吧,还有这辆魔鬼卡车和他的主人......While driving in a highway to the wedding of his beloved Betty-Ann, Adam is surprised by his former schoolmate Harley on the backseat of his car. Adam has broken off with the inconvenient and moron Harley because of Betty-Ann. Along their road trip, Harley makes fun of some rednecks in a bar and later their car is chased by a giant monster truck on the road. After some incidents, they give a lift to the hitchhiker Sarah and sooner the trio is terrorized by a scary monster driving the monster truck.