居住在纽约的摩根夫妇生活优渥,丈夫保罗(休·格兰特 Hugh Grant 饰)在司法界声名远播,妻子梅莉(莎拉·杰茜卡·帕克 Sarah Jessica Parker 饰)则是房地产界的精英女强人。事业上的卓越成就无法弥合夫妇俩日渐凸现的情感矛盾,保罗的外遇更致使两人长期分居,婚姻濒临崩溃。在分居后的第三个月,保罗主动约出妻子,希望与之重归于好。晚餐过后,摩根夫妇在瓢泼大雨中偶然目睹一桩杀人案,他们清楚看到凶手(麦克·凯利 Michael Kelly 饰)的长相,而自己的容貌也被凶手尽收眼底。 摩根夫妇此时恐怕首次要为自己的知名度而懊恼,因为凶手文森特毫不费力知道了他们的姓名。针对摩根夫妇的灭口追杀自此接连上演,他们只有抛弃一切,选择人间蒸发……Meryl and Paul Morgan have separated since his infidelity. He's a Manhattan lawyer, seeking forgiveness. She's moved on, focusing on real estate sales. As he walks her to an appointment one evening, pleading his case, they witness a murder; the murderer sees them. The FBI wants them in witness protection until the killer is caught. He's already hunting them. The FBI sends them to Ray, Wyoming, a tiny ranch town, where they stay with the aging sheriff and his gun-toting wife (who's his deputy). Meryl and Paul must sort out their relationship while their New York ways bump up against those of the West. Meantime, Meryl knows two things that Paul doesn't.