在一次普通的演习里,杰克作为部队的首领,不幸使自己的手下感染上了某种病毒。人类只要一旦染上这种病毒,就会逐渐变异成为狼。然而,杰克身处困境,不但自己要与病毒抗争,还要避开狼人的威胁。最终,他带领三位女战士,与狼人的邪恶力量展开战斗。正义与邪恶的抗衡,又一次展开了风云对决。Jack Ford leads a special forces unit back to the United States to hunt down Jake Gabriel, a soldier who has been infected with the werewolf virus that turns man into wolf. Little does Jack know that three of the female soldiers serving in his unit have also been infected and have already transformed into she-wolves. The she-wolves' forces of evil and Ford's special op forces of good, are pitted against each other in the race to save mankind from turning into wolves.