钱斯(迈克尔·J·福克斯 Michael J. Fox 配音)、塞西(莎莉·菲尔德 Sally Field 配音)和阴影(唐·阿米契 Don Ameche 配音)是三位相处多年的好友,彼此之间感情十分要好。不过,值得一提的是,它们三位并非人类,而是小主人莫利(Mariah Milner 饰)饲养的宠物。 某日,由于工作的关系,莫利的父母将这两狗一猫暂时寄养在朋友的农场中,然而,早就习惯了主人日日陪伴的他们误以为遭到了抛弃,心中充满了不安和恐惧,三位小能手决定联合起来踏上旅途,靠自己的力量找到回家的路。对于三只动物来说,这一路充满了变故与风险,凭借着小小的身躯,它们真的能够如愿回到主人的怀抱吗?Three pets (Chance, a young dog unfamiliar with the world; Shadow, an aging, wise dog; and Sassy, a snobby cat) are left behind when their family goes on vacation. Unsure of what happened, the animals set out on a quest to find their family. This journey across America is very dangerous and the animals risk never seeing their masters again. The group of pets travel across forested mountains and areas of wide-open countryside, while their family searches for them in the same areas.